Publications

Research Articles:

2026

• Myeloid Fmr1 deficiency in mice results in reduced serum cholesterol and altered bile pathway gene expression

  Xiaoning Zhao, Jianchang Zhou, Kuang-Yuh Chyu, Ebru Erbay, Bojan Cercek, Prediman K Shah, Paul C Dimayuga

2025

• Targeting ire1 kinase and fmrp for prophylaxis, management and treatment of atherosclerosis

  Ebru Erbay, Zehra Yildirim

2023

• Universal DNA methylation age across mammalian tissues

  Lu AT, Fei Z, Haghani A, Robeck TR, Zoller JA, Li CZ, Lowe R, Yan Q, Zhang J, Vu H, Ablaeva J, Acosta-Rodriguez VA, Adams DM, Almunia J, Aloysius A, Ardehali R, Arneson A, Baker CS, Banks G, Belov K, Bennett NC, Black P, Blumstein DT, Bors EK, Breeze CE, Brooke RT, Brown JL, Carter GG, Caulton A, Cavin JM, Chakrabarti L, Chatzistamou I, Chen H, Cheng K, Chiavellini P, Choi OW, Clarke SM, Cooper LN, Cossette ML, Day J, DeYoung J, DiRocco S, Dold C, Ehmke EE, Emmons CK, Emmrich S, Erbay E, Erlacher-Reid C, Faulkes CG, Ferguson SH, Finno CJ, Flower JE, Gaillard JM, Garde E, Gerber L, Gladyshev VN, Gorbunova V, Goya RG, Grant MJ, Green CB, Hales EN, Hanson MB, Hart DW, Haulena M, Herrick K, Hogan AN, Hogg CJ, Hore TA, Huang T, Izpisua Belmonte JC, Jasinska AJ, Jones G, Jourdain E, Kashpur O, Katcher H, Katsumata E, Kaza V, Kiaris H, Kobor MS, Kordowitzki P, Koski WR, Krützen M, Kwon SB, Larison B, Lee SG, Lehmann M, Lemaitre JF, Levine AJ, Li C, Li X, Lim AR, Lin DTS, Lindemann DM, Little TJ, Macoretta N, Maddox D, Matkin CO, Mattison JA, McClure M, Mergl J, Meudt JJ, Montano GA, Mozhui K, Munshi-South J, Naderi A, Nagy M, Narayan P, Nathanielsz PW, Nguyen NB, Niehrs C, O'Brien JK, O'Tierney Ginn P, Odom DT, Ophir AG, Osborn S, Ostrander EA, Parsons KM, Paul KC, Pellegrini M, Peters KJ, Pedersen AB, Petersen JL, Pietersen DW, Pinho GM, Plassais J, Poganik JR, Prado NA, Reddy P, Rey B, Ritz BR, Robbins J, Rodriguez M, Russell J, Rydkina E, Sailer LL, Salmon AB, Sanghavi A, Schachtschneider KM, Schmitt D, Schmitt T, Schomacher L, Schook LB, Sears KE, Seifert AW, Seluanov A, Shafer ABA, Shanmuganayagam D, Shindyapina AV, Simmons M, Singh K, Sinha I, Slone J, Snell RG, Soltanmaohammadi E, Spangler ML, Spriggs MC, Staggs L, Stedman N, Steinman KJ, Stewart DT, Sugrue VJ, Szladovits B, Takahashi JS, Takasugi M, Teeling EC, Thompson MJ, Van Bonn B, Vernes SC, Villar D, Vinters HV, Wallingford MC, Wang N, Wayne RK, Wilkinson GS, Williams CK, Williams RW, Yang XW, Yao M, Young BG, Zhang B, Zhang Z, Zhao P, Zhao Y, Zhou W, Zimmermann J, Ernst J, Raj K, Horvath S.

• DNA methylation networks underlying mammalian traits

  Haghani A, Li CZ, Robeck TR, Zhang J, Lu AT, Ablaeva J, Acosta-Rodríguez VA, Adams DM, Alagaili AN, Almunia J, Aloysius A, Amor NMS, Ardehali R, Arneson A, Baker CS, Banks G, Belov K, Bennett NC, Black P, Blumstein DT, Bors EK, Breeze CE, Brooke RT, Brown JL, Carter G, Caulton A, Cavin JM, Chakrabarti L, Chatzistamou I, Chavez AS, Chen H, Cheng K, Chiavellini P, Choi OW, Clarke S, Cook JA, Cooper LN, Cossette ML, Day J, DeYoung J, Dirocco S, Dold C, Dunnum JL, Ehmke EE, Emmons CK, Emmrich S, Erbay E, Erlacher-Reid C, Faulkes CG, Fei Z, Ferguson SH, Finno CJ, Flower JE, Gaillard JM, Garde E, Gerber L, Gladyshev VN, Goya RG, Grant MJ, Green CB, Hanson MB, Hart DW, Haulena M, Herrick K, Hogan AN, Hogg CJ, Hore TA, Huang T, Izpisua Belmonte JC, Jasinska AJ, Jones G, Jourdain E, Kashpur O, Katcher H, Katsumata E, Kaza V, Kiaris H, Kobor MS, Kordowitzki P, Koski WR, Krützen M, Kwon SB, Larison B, Lee SG, Lehmann M, Lemaître JF, Levine AJ, Li X, Li C, Lim AR, Lin DTS, Lindemann DM, Liphardt SW, Little TJ, Macoretta N, Maddox D, Matkin CO, Mattison JA, McClure M, Mergl J, Meudt JJ, Montano GA, Mozhui K, Munshi-South J, Murphy WJ, Naderi A, Nagy M, Narayan P, Nathanielsz PW, Nguyen NB, Niehrs C, Nyamsuren B, O'Brien JK, Ginn PO, Odom DT, Ophir AG, Osborn S, Ostrander EA, Parsons KM, Paul KC, Pedersen AB, Pellegrini M, Peters KJ, Petersen JL, Pietersen DW, Pinho GM, Plassais J, Poganik JR, Prado NA, Reddy P, Rey B, Ritz BR, Robbins J, Rodriguez M, Russell J, Rydkina E, Sailer LL, Salmon AB, Sanghavi A, Schachtschneider KM, Schmitt D, Schmitt T, Schomacher L, Schook LB, Sears KE, Seifert AW, Shafer ABA, Shindyapina AV, Simmons M, Singh K, Sinha I, Slone J, Snell RG, Soltanmohammadi E, Spangler ML, Spriggs M, Staggs L, Stedman N, Steinman KJ, Stewart DT, Sugrue VJ, Szladovits B, Takahashi JS, Takasugi M, Teeling EC, Thompson MJ, Van Bonn B, Vernes SC, Villar D, Vinters HV, Vu H, Wallingford MC, Wang N, Wilkinson GS, Williams RW, Yan Q, Yao M, Young BG, Zhang B, Zhang Z, Zhao Y, Zhao P, Zhou W, Zoller JA, Ernst J, Seluanov A, Gorbunova V, Yang XW, Raj K, Horvath S.

2022

• ER Stress-Induced Sphingosine-1-Phosphate Lyase Phosphorylation Potentiates the Mitochondrial Unfolded Protein Response

  Yildirim AD, Citir M, Dogan AE, Veli Z, Yildirim Z, Tufanli O, Traynor-Kaplan A, Schultz C, Erbay E.

• PACT establishes a posttranscriptional brake on mitochondrial biogenesis by promoting the maturation of miR-181c

  Dogan AE, Hamid SM, Yildirim AD, Yildirim Z, Sen G, Riera CE, Gottlieb RA, Erbay E.

• Intercepting IRE1 kinase-FMRP signaling prevents atherosclerosis progression

  Yildirim Z, Baboo S, Hamid SM, Dogan AE, Tufanli O, Robichaud S, Emerton C, Diedrich JK, Vatandaslar H, Nikolos F, Gu Y, Iwawaki T, Tarling E, Ouimet M, Nelson DL, Yates JR 3rd, Walter P, Erbay E.

• Targeting IRE1 endoribonuclease activity alleviates cardiovascular lesions in a murine model of Kawasaki disease vasculitis

  Marek-Iannucci S, Yildirim AD, Hamid SM, Ozdemir AB, Gomez AC, Kocatürk B, Porritt RA, Fishbein MC, Iwawaki T, Noval Rivas M, Erbay E, Arditi M.

• S-adenosylmethionine inhibits la ribonucleoprotein domain family member 1 in murine liver and human liver cancer cells

  Ramani K, Robinson AE, Berlind J, Fan W, Abeynayake A, Binek A, Barbier-Torres L, Noureddin M, Nissen NN, Yildirim Z, Erbay E, Mato JM, Van Eyk JE, Lu SC.

2020

• Inositol-requiring enzyme-1 regulates phosphoinositide signaling lipids and macrophage growth

  Hamid SM, Citir M, Terzi EM, Cimen I, Yildirim Z, Dogan AE, Kocaturk B, Onat UI, Arditi M, Weber C, Traynor-Kaplan A, Schultz C, Erbay E.

2019

• Double bond configuration of palmitoleate is critical for atheroprotection

  Cimen I, Yildirim Z, Dogan AE, Yildirim AD, Tufanli O, Onat UI, Nguyen U, Watkins SM, Weber C, Erbay E.

• Intercepting the Lipid-Induced Integrated Stress Response Reduces Atherosclerosis

  Onat UI, Yildirim AD, Tufanli Ö, Çimen I, Kocatürk B, Veli Z, Hamid SM, Shimada K, Chen S, Sin J, Shah PK, Gottlieb RA, Arditi M, Erbay E.

2018

• Chlamydia pneumoniae Hijacks a Host Autoregulatory IL-1β Loop to Drive Foam Cell Formation and Accelerate Atherosclerosis

  Tumurkhuu G, Dagvadorj J, Porritt RA, Crother TR, Shimada K, Tarling EJ, Erbay E, Arditi M, Chen S.

• Chlamydia and Lipids Engage a Common Signaling Pathway That Promotes Atherogenesis

  Chen S, Shimada K, Crother TR, Erbay E, Shah PK, Arditi M.

2017

• Targeting IRE1 with small molecules counteracts progression of atherosclerosis

  Ozlem Tufanli, Pelin Telkoparan Akillilar, Diego Acosta-Alvear, Begum Kocaturk, Umut Inci Onat, Syed Muhammad Hamida, Ismail Çimen, Peter Walter, Christian Weber, and Ebru Erbay

2016

• Prevention of atherosclerosis by bioactive palmitoleate through suppression of organelle stress and inflammasome activation

  Ismail Cimen, Begum Kocaturk, Seda Koyuncu, Ozlem Tufanli, Umut I. Onat,  Asli D. Yildirim, Onur Apaydin, Seyma Demirsoy, Zaliha G. Aykut, Uyen T. Nguyen,  Steven M. Watkins, Gokhan S. Hotamisligil, and Ebru Erbay

2011

• Macrophage Mal1 Deficiency Suppresses Atherosclerosis in Low-Density Lipoprotein Receptor–Null Mice by Activating Peroxisome Proliferator-Activated Receptor-γ–Regulated Genes

  Vladimir R. Babaev, Robert P. Runner, Daping Fan, Lei Ding, Youmin Zhang, Huan Tao, Ebru Erbay, Cem Z. Görgün, Sergio Fazio, Gökhan S.Hotamisligil, and MacRae F. Linton

2009

• Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis

  Ebru Erbay, Vladimir R Babaev, Jared R Mayers, Liza Makowski, Khanichi N Charles, Melinda E Snitow, Sergio Fazio, Michelle M Wiest, Steven M Watkins, Macrae F Linton, Gokhan S Hotamisligil

2006

• A genetic variant at the fatty acid-binding protein aP2 locus reduces the risk for hypertriglyceridemia, type 2 diabetes, and cardiovascular disease

  G Tuncman, E Erbay, X Hom, I De Vivo, H Campos, E B Rimm, G S Hotamisligil

2005

• Skeletal myocyte hypertrophy requires mTOR kinase activity and S6K1

  In-Hyun Park, Ebru Erbay, Paul Nuzzi, Jie Chen

2003

• IGF-II transcription in skeletal myogenesis is controlled by mTOR and nutrients

  Ebru Erbay, In-Hyun Park, Paul D Nuzzi, Christopher J Schoenherr, Jie Chen

Reviews:

2024

• Institutional Support for the Career Advancement of Women Faculty in Science and Academic Medicine: Successes, Challenges, and Future Directions

  Zhen Bouman Chen, Elena Aikawa, Mabruka Alfaidi, Kamilah Ali, Cassandra L Clift, Ebru Erbay, Gabrielle Fredman, Delphine Gomez, Ngan F Huang, Hong S Lu, Patricia K Nguyen, Suellen Darc Oliveira, Paula Rodriguez-Miguelez, Gopika SenthilKumar, Hanrui Zhang; by the ATVB WLC

2018

• Regulation of macrophage immunometabolism in atherosclerosis

  Koelwyn GJ, Corr EM, Erbay E, Moore KJ.

2015

• Fine-tuning inflammasome activity with a small molecule or ketogenic diet

  Ebru Erbay

2014

• ER-Mitochondrial Communication Gets Stressful

  Ebru Erbay

• BETing on the Therapeutic Potential of Super Enhancers

  Ebru Erbay

• Stress (In)Flames Atherosclerosis

  Ebru Erbay

• Sumo Wrestling Atherosclerosis

  Ebru Erbay

• Bacteria-Driven Atherosclerosis

  Ebru Erbay

• Turbulent Times for the Atherosclerosis Epigenome

  Ebru Erbay

• Micro(RNA)managing Endothelial Regeneration

  Ebru Erbay

2008

• Nutrient sensing and inflammation in metabolic diseases

  Gokhan S. Hotamisligil & Ebru Erbay

Book Chapters:

• Erbay E., Kim J., and Chen J. “Nutrient-dependent regulation of mTOR”.
  Book chapter for “Nutrients and Cell Signaling” by Marcel Dekker Inc., New
  York, 2005
• Erbay, E. and Hotamisligil, G.S. Inflammatory causes of obesity and
  metabolic diseases. Book chapter for “The Handbook of Obesity - 3rd
  edition” by Taylor and Francis., New York, in press